(Huang et al., 2021 | J Nutr Biochem.) NMN administration decreases the levels of P16 protein. The protein level of p16 increases with age, reaching a peak in the 60-week control (60WC) group. Mice treated with NMN for 20 weeks beginning at 40 weeks of age (60WN) showed significantly decreased levels of p16. These results indicate that the ovarian status of mice in the 60WN group was relatively younger after NMN supplementation.


Can a supplement a day keep ovarian aging at bay?

The importance of issues related to ovarian aging has been increasing progressively over the past several decades since, increasingly, more couples in all developed countries choose to postpone parenthood to more advanced female ages. This trend affects the likelihood of fertilization and conception, whether resulting from natural conception, conventional in vitro fertilization (IVF), or intracytoplasmic sperm injection (ICSI).

Since advanced male age seems to have little effect on the success rate for IVF/ICSI attempts using oocytes from young donors, much of the attention to improving the chances of parenthood has pointed to improving ovarian aging. Though treatment options need to be fine-tuned to reflect each woman’s condition, it is possible that supplementing with NMN can go a long way for improving the chances to experience some of life’s most miraculous adventures: pregnancy, childbirth, and parenthood.